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Comment: Barbiturates could raise adverse consequences, including respiratory depression, made by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and reduce blood concentrations of TCAs.Scientific laboratory reference values should be used to ascertain the therapeutic anticonvulsant volume of phenobarbital in

phenobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers may well raise the metabolism of ifosfamide to its Energetic alkylating metabolites.All through pregnancy, this medication should be utilized only when clearly needed. It may well hurt an unborn newborn.